Adriana Zeevi, Ph.D. (D) ABH

Adriana Zeevi, Ph.D. (D) ABH

Contact

Office: BST W1551

Lab: BST

Ph: 412-624-1073

Fax: 412-624-6666

zeevi@pitt.edu

Website »

Education

  • B.A. - Bar-Ilan University
  • M.S.A. - Bar-Ilan University
  • Ph.D. - Bar-Ilan University

Academic Affiliation

  • Professor of Surgery
  • Professor of Pathology
  • Professor of Immunology

About Research

Despite improved immunosuppression protocols, most transplant recipients face a variety of complications. Early post-transplant is important to discriminate between infection and rejection. Drug toxicity, chronic rejection and malignancies are long-term complications. Dr. Zeevi's research interests are focused in the area of immunologic monitoring of solid organ transplant recipients:

  1. Cellular assay to determine the host immune competence and responses to recall antigens (CMV, EBV and other).
  2. Evaluation of T helper cell function and cytokine profile upon stimulation with donor-specific alloantigen.
  3. The impact of cytokine gene polymorphism in solid organ transplantation and its predictive value for individualized immunosuppressive protocols.
  4. The role of HLA-specific and non-HLA antibodies in solid organ transplantation.
  5. The implementation of novel Luminex platform C1q binding assay to detect complement fixing donor-specific anti HLA antibodies in patient sera and to correlate this functional assay with clinical outcomes including the efficacy of protocols used to desensitize transplant candidates and/or to treat antibody mediated rejection in solid organ transplant recipients.

Selected Publications

Ohmann EL, Brooks MM, Webber SA, Girnita DM, Ferrell RE, Burckart GJ, Chinnock R, Canter C, Addonizio L, Bernstein D, Kirklin JK, Naftel DC, Zeevi A. Association of genetic polymorphisms and risk of late post-transplantation infection in pediatric heart recipients. J Heart Lung Transplant 2010: 14: 891-5

Girnita A, Mazariegos GV, Castellaneta A, Reyes J, Bentlejewski C, Thomson AW, Zeevi A. Liver transplant recipients weaned off immunosuppression lack circulating donor-specific antibodies. Hum Immunol; 2010; 71: 274-6

Girnita DM, Ohmann EL, Brooks MM, Webber SA, Burckart GJ, Ferrell RE, Ranganathan S, Chinnock R, Canter C, Addonizio L, Bernstein D, Kirklin JK, Naftel DC, Zeevi A. Gene polymorphisms impact the risk of rejection with hemodynamic compromise: A multicenter study. Transplantation 2011: 91: 1326-1332

Mitsani D, Nguyen MJ, Girnita DM, Spichty K, Kwak EJ, Silveira FP, Toyoda Y, Pilewski JM, Crespo M, Bhama JK, Abdel-Massih R, Zaldonis D, Zeevi A, Clancy CJ. A polymorphism linked to elevated levels of interferon-y is associated with an increased risk of cytomegalovirus disease among Caucasian lung transplant recipients at a single center. J Heart Lung Transplant: 2011: 30: 523-9

Kobasgigawa, J Crespo-Leiro MG, Ensminger SM, Reichenspurner H, Angelini A, Berry G, Burke M, Czer L, Hiemann N, Kfoury AG, Mancini D, Mohacsi P, Patel J, Pereira N, Platt JL, Reed F, Reinsomen N, Rodriguez ER, Rose ML, Russell SD, Suciu-Foca N, Tallaj J, Taylor DO, Van Bakel A, West L , Zeevi A, Zuckermann A; Consensus Conference Participant. Report from a consensus conference on antibody-mediated rejection in heart transplantation. J Heart Lung Transplant 2011: 30: 252-69

A Zeevi, M. Marrari , B Feingold, S Webber, R J. Duquesnoy; Human leukocyte antigen epitope analysis to assess complement- and non-complement-binding donor-specific antibody repertoire in a pediatric heart transplant recipient. Hum Immunol; 2012:73:48-51

View Complete Publications Listing

Research Interests

  • Immunologic monitoring of solid organ transplant recipients
  • Characterization of the immune response to cytomegalovirus in immunocompromised solid organ transplant recipients as well as in normals
  • The role of cell migration and chimerism in solid organ transplant acceptance and tolerance induction