Hassane M. Zarour, M.D.
Office: 1.32a HCC
- M.D. (Dermatology) - University of Marseille
- Postdoc - Ludwig Institute for Cancer Research, Brussels, Belgium
- Postdoc - University of Pittsburgh Cancer Institute
- Professor of Medicine, Immunology and Dermatology
- Co-Leader, Melanoma Program, University of Pittsburgh Cancer Institute
Identification of MHC class II tumor epitopes derived from the cancer-germline (also called cancer-testis) antigens expressed by melanomas and other solid tumors (NY-ESO-1/LAGE-1). Special emphasis on promiscuous DR-restricted and DP4-restricted epitopes.
Analysis of the CD4+ T cell responses induced by tumor epitopes, protein and CpG in association with different subsets of dendritic cells.
Analysis of spontaneous cellular (CD8 and CD4+ T cells) and humoral responses against these antigens from the blood of patients with melanoma and other solid tumors.
Dissection of cellular and humoral responses in patients with melanoma and other solid tumors undergoing peptide-based and protein-based vaccine therapy in association with CpG oligonucleotides.
Fourcade, J., Z. Sun,O.Pagliano, P. Guillaume, I. F. Luescher, C. Sander, J. M. Kirkwood, D. Olive, V. Kuchroo, and H. M. Zarour. 2012. CD8+ T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1. Cancer Res, 2012
Fourcade, J., Z. Sun, M. Benalloua, P. Guillaume, I. F. Luescher, C. Sander, J. M. Kirkwood, V. Kuchroo, and H. M. Zarour. 2010. Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients J Exp Med 207:2175-86. PMID: 20819923
Fourcade, J., Z. Sun, P. Kudela, B. Janjic, J. M. Kirkwood, T. El-Hafnawy, and H. M. Zarour. 2010. Human Tumor Antigen-Specific Helper and Regulatory T Cells Share Common Epitope Specificity but Exhibit Distinct T Cell Repertoire. J Immunol 182:5240-9. PMCID: 20483736
Fourcade, J., P. Kudela, Z. Sun, H. Shen, S. R. Land, D. Lenzner, P. Guillaume, I. F. Luescher, C. Sander, S. Ferrone, J. M. Kirkwood, and H. M. Zarour. 2009. PD-1 is a regulator of NY-ESO-1-specific CD8+ T cell expansion in melanoma patients. J Immunol 182:5240-5249. PMID: 19380770
Fourcade, J., P. Kudela, P. A. Andrade Filho, B. Janjic, S. R. Land, C. Sander, A. Krieg, A. Donnenberg, H. Shen, J. M. Kirkwood, and H. M. Zarour. 2008. Immunization with analog peptide in combination with CpG and montanide expands tumor antigen-specific CD8+ T cells in melanoma patients. J Immunother 31:781-791. PMID: 18779741
- Mechanisms of tumor-induced T cell dysfunction
- Targeting Inhibitory pathways to reverse tumor-induced T cell dysfunction in cancer patients
- Cancer vaccines and immunotherapy of cancer