Lisa Borghesi, PhD

Lisa Borghesi, PhD

Contact

Campus: 200 Lothrop St

Office: BSTWR E1056

Pittsburgh, PA 15261

Ph: 412-383-7074

Fax: 412-383-8098

borghesi@pitt.edu

Education

  • PhD - UConn

Academic Affiliation

  • Associate Professor
  • Scientific Director, Unified Flow Core
  • Executive Committee of the Faculty, Elected Member
  • Chair, AAI Advocacy Programs subcommittee

About Research

Dr. Borghesi's research focuses on HSCs, the sole source of blood forming cells throughout life. It has long been known that infection triggers dramatic and rapid changes in hematopoietic output but the mechanisms remain murky. TLR4 is a dominant innate immune sensor for LPS and hence a model receptor for how the hematopoietic system adapts to pathogen exposure. Her laboratory is studying the mechanisms that enable stem cells to directly sense infection, and functionally respond with accelerated differentiation and/or lineage fate re-direction.

Dr. Borghesi's publications appear in the Journal of Experimental Medicine, PNAS, and Nature Immunology, and are frequently ranked by the Faculty of 1000.

 

 

2015 LAB NEWS:

  • Dr. Lily Fu joins the lab as a Visiting Scholar
  • Lisa gives plenary talk at IESCC stem cell sympoisum at UCRiverside
  • Research Associates Kate Chen and Weijian Jiang arrive
  • Ailing's J Immunol Cutting-Edge paper published in Sept 15th issue
  • Lisa delivers talk at 4th European Congress of Immunology, Vienna
  • Lisa awarded new NIH grant on the mechanisms by which bone marrow precursors sense inflammation and re-direct lineage output

 

 

Selected Publications

Liu A, Y Wang, Y Ding, I Baez, K Payne & L Borghesi (2015) Hematopoietic stem cell expansion and common lymphoid progenitor depletion requires hematopoietic-derived, cell-autonomous TLR4 in a model of chronic endotoxin. J Immunol (Cutting-Edge) 195:2524-2528

Borghesi L (2014) Hematopoiesis in steady-state versus stress: self-renewal, lineage fate choice, and the conversion of danger signals into cytokine signals in HSCs. J Immunol 193:2053-2058

Santos P, Y. Ding and L Borghesi (2014) Cell-intrinsic in vivo requirement for the E47-p21 pathway in long-term hematopoietic stem cells. J Immunol 192:160-168

Editor’s pick - http://www.jimmunol.org/content/192/1/1.full

Esplin, B, T Shimazu, R Welner, K Garrett, M Frank, L Nie, Q Zhang, M Humphrey, Q Yang, L Borghesi & P Kincade (2011) Chronic exposure to a TLR ligand injures hematopoietic stem cells. J Immunol 186:5367-5375

Ranked by Faculty of 1000 - http://f1000.com/prime/10246956

Yang Q, B Esplin & L Borghesi (2011) E47 regulates hematopoietic stem cell proliferation and energetics but not myeloid lineage restriction. Blood 117:3529-3538

Martincic K, S Alkan, A Cheatle, L Borghesi & C Milcarek (2009) Transcription elongation factor ELL2 directs Ig secretion in plasma cells by stimulating altered RNA processing. Nat Immunol 10:1102-1109

Yang Q, L Kardava, A St Leger, K Martincic, B Varnum-Finney, I Bernstein, C Milcarek & L Borghesi (2008) E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors. J Immunol 181:5885-5894

     Editor’s pick - www.jimmunol.org/content/181/9/5811.full

Borghesi L, J Aites, S Nelson, P Lefterov, P James & R Gerstein (2005) E47 is required for V(D)J recombinase activity in common lymphoid progenitors. J Exp Med 12:1669-1677

Ranked by Faculty of 1000 - http://f1000.com/prime/1017620

Lab Information

The Borghesi lab has new grant funding to study inflammation and immunity. Graduate students interested in 2015-2016 rotation opportunities should contact Dr. Borghesi.