Lisa Borghesi, PhD

Lisa Borghesi, PhD

Contact

Office: E1058 BST

Lab: E1011 BST

Ph: 412-383-7074

Fax: 412-383-8098

borghesi@pitt.edu

Education

  • PhD - UConn

Academic Affiliation

  • Associate Professor
  • Director, Immunology Flow Cytometry Facility
  • Member, Cancer Immunology Program

About Research

Dr. Borghesi's research focuses on HSCs, the sole source of blood forming cells throughout life. It has long been known that infection triggers dramatic and rapid changes in hematopoietic output but the mechanisms remain murky. TLR4 is a dominant innate immune sensor for LPS and hence a model receptor for how the hematopoietic system adapts to pathogen exposure. Her laboratory is studying the mechanisms that enable stem cells to directly sense infection, and functionally respond with accelerated differentiation and/or lineage fate re-direction. Dr. Borghesi's publications appear in the Journal of Experimental Medicine, PNAS, and Nature Immunology, and are frequently ranked by the Faculty of 1000.

 

 

Selected Publications

Borghesi, L (2014) Hematopoiesis in steady-state versus stress: self-renewal, lineage fate choice, and the conversion of danger signals into cytokine signals in HSCs. J. Immunol. in press

Santos P, Y. Ding and L Borghesi (2014) Cell-intrinsic in vivo requirement for the E47-p21 pathway in long-term hematopoietic stem cells. J. Immunol. 192:160-168

Editor’s pick - http://www.jimmunol.org/content/192/1/1.full

Esplin, B, T Shimazu, R Welner, K Garrett, M Frank, L Nie, Q Zhang, M Humphrey, Q Yang, L Borghesi & P Kincade (2011) Chronic exposure to a TLR ligand injures hematopoietic stem cells J. Immunol. 186:5367-5375

Ranked by Faculty of 1000 - http://f1000.com/prime/10246956

Yang Q, B Esplin & L Borghesi (2011) E47 regulates hematopoietic stem cell proliferation and energetics but not myeloid lineage restriction. Blood 117:3529-3538

Martincic K, S Alkan, A Cheatle, L Borghesi & C Milcarek (2009) Transcription elongation factor ELL2 directs Ig secretion in plasma cells by stimulating altered RNA processing. Nat Immunol 10:1102-1109

Yang Q, L Kardava, A St Leger, K Martincic, B Varnum-Finney, I Bernstein, C Milcarek & L Borghesi (2008) E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors. J Immunol 181:5885-5894

     Editor’s pick - www.jimmunol.org/content/181/9/5811.full

Borghesi L, J Aites, S Nelson, P Lefterov, P James & R Gerstein (2005) E47 is required for V(D)J recombinase activity in common lymphoid progenitors. J Exp Med 12:1669-1677

Ranked by Faculty of 1000 - http://f1000.com/prime/1017620

Complete List of Publications