Theresa L. Whiteside, Ph.D.

Theresa L. Whiteside, Ph.D.

Contact

Office: 1.32d HCC

Lab: HCC

Ph: 412-624-0096

Fax: 412-624-0264

whitesidetl@upmc.edu

Education

  • B.S. - Columbia University
  • M.A. - Columbia University
  • Ph.D. - Columbia University

Academic Affiliation

  • Professor of Pathology
  • Professor of Immunology
  • Professor of Otolaryngology

About Research

Dr. Whiteside’s research interests are in Tumor Immunology and Immunotherapy with special focus on mechanisms of tumor-induced immunosuppression, cytokine networks, development of anticancer vaccines, immunology of human head and neck cancer and the role of natural immunity in the control of cancer progression. Her research is in mechanisms of tumor escape from the host immune system and the development of therapies designed to eliminate tumor escape. Currently she is investigating the role of regulatory T cells in cancer progression as well as contributions of tumor-derived microvesicles (MV) to apoptosis of CD8+ effector cells in the peripheral circulation of patients with cancer and in the tumor microenvironment. Dr. Whiteside is also interested in dendritic cells (DC) as vehicles for delivering tumor antigens to T cells. She is investigating components of antigen processing machinery (APM) in human DC with an objective of defining and optimizing conditions for optimal antigen processing and cross-presentation. She is a recognized expert in immune monitoring of patients with cancer. Since 2002, she has served on numerous NIH and DOD study sections, and is a past member of the Board of Scientific Counselors for NIDCR. She is a member of numerous journal editorial boards and a scientific reviewer for many other scientific journals. She has authored 503 peer-reviewed publications in scientific journals and 115 chapters and review articles. She is the author of a book on human tumor-infiltrating lymphocytes and co-editor of several scientific books. Over the years, she has trained over 80 post-doctoral fellows from the United States and abroad.

Selected Publications

Whiteside TL. Immune responses to malignancies. J. Allergy Clinical Immunology 125:S272-83, 2010.

Szajnik M, Czystowska M, Szczepanski MJ, Mandapathil M, Whiteside TL. Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T cells (Treg). PLoS ONE, 5(7): e11469, 2010.

Mandapathil M, Szczepanski MJ, Szajnik M, Ren J, Jackson EK, Johnson JT, Gorelik E, Lang S, Whiteside TL. Adenosine and prostaglandin E2 cooperate in the suppression of immune responses mediated by adaptive regulatory T cells. J. Biol. Chem, 285: 27571-80, 2010.

Schuler PJ, Harasymczuk M, Schilling B, Lang S, Whiteside TL. Separation of human CD4+CD39+ T cells by magnetic beads reveals two phenotypically and functionally different subsets. J. Immunol. Meth., 369: 59-68, 2011.

Mandapathil M., Whiteside TL. Targeting human regulatory T cells (Treg) in patients with cancer: blocking of adenosine-prostaglandin E2 cooperation. Exp Opin Biol Ther, 11(9): 1203-1214, 2011.

View Complete Publications Listing

Research Interests

  • Immunology and immunotherapy of human solid tumors
  • Development of anti-cancer vaccines
  • Studies of dendritic cells in cancer
  • Immune monitoring of cancer patients treated with biotherapies
  • Immune suppression in cancer and its mechanisms
  • Cytokines in health and disease