Fadi George Lakkis, MD

Fadi George Lakkis, MD

Contact

Office: 200 Lothrop St., BST W1548

Lab: 200 Lothrop St., BST W1500

Pittsburgh, PA 15261

Ph: 412-383-5774

Fax: 412-383-9990

lakkisf@upmc.edu

Education

  • MD, American University of Beirut, Lebanon

Academic Affiliation

  • Frank & Athena Sarris Chair in Transplantation Biology
  • Professor, Dept. of Surgery, Immunology, and Medicine
  • Scientific Director, Thomas E. Starzl Transplantation Institute

About Research

The goal of my research is to understand the fundamental mechanisms of acute and chronic rejection in solid organ transplantation. The principal areas of investigation in my laboratory are the innate mechanisms responsible for initiating and perpetuating the alloimmune response and the role of memory T cells in allograft rejection.  Mouse models of skin, heart, kidney, and islet transplantation are employed to address these areas of investigation.  Intravital multiphoton microscopy is used to investigate the mechanisms of memory T cell migration to the transplanted mouse kidney and their interactions with antigen presenting cells.  My lab is also part of a human immunology group investigating innate and adaptive immune function in kidney transplant recipients.

Selected Publications

Original Manuscripts:

Non-self recognition by monocytes initiates allograft rejection.

Oberbarnscheidt MH, Zeng Q, Li Q, Dai H, Williams AL, Shlomchik WD, Rothstein DM, Lakkis FG.

J Clin Invest. 2014 Aug 1;124(8):3579-89. doi: 10.1172/JCI74370

Cognate antigen directs CD8+ T cell migration to vascularized transplants.

Walch JM, Zeng Q, Li Q, Oberbarnscheidt MH, Hoffman RA, Williams AL, Rothstein DM, Shlomchik WD, Kim JV, Camirand G, Lakkis FG

J Clin Invest. 2013 Jun 3;123(6):2663-71. doi: 10.1172/JCI66722.

Allograft outcomes in outbred mice.

Reichenbach DK, Li Q, Hoffman RA, Williams AL, Shlomchik WD, Rothstein DM, Demetris AJ, Lakkis FG.

Am J Transplant. 2013 Mar;13(3):580-8. doi: 10.1111/ajt.12056.

Multiphoton intravital microscopy of the transplanted mouse kidney.

Camirand G, Li Q, Demetris AJ, Watkins SC, Shlomchik WD, Rothstein DM, Lakkis FG.

Am J Transplant. 2011 Oct;11(10):2067-74. doi: 10.1111/j.1600-6143.2011.03671.x.

An innate response to allogeneic nonself mediated by monocytes.

Zecher D, van Rooijen N, Rothstein DM, Shlomchik WD, Lakkis FG.

J Immunol. 2009 Dec 15;183(12):7810-6. doi: 10.4049/jimmunol.0902194.

Contribution of naïve and memory T-cell populations to the human alloimmune response.

Macedo C, Orkis EA, Popescu I, Elinoff BD, Zeevi A, Shapiro R, Lakkis FG, Metes D.

Am J Transplant. 2009 Sep;9(9):2057-66. doi: 10.1111/j.1600-6143.2009.02742.x.

Embryonic chimerism does not induce tolerance in an invertebrate model organism.

Poudyal M, Rosa S, Powell AE, Moreno M, Dellaporta SL, Buss LW, Lakkis FG.

Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4559-64.

Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection.

Goldstein DR, Tesar BM, Akira S, Lakkis FG.

J Clin Invest. 2003 May;111(10):1571-8.

Recall and propagation of allospecific memory T cells independent of secondary lymphoid organs.

Chalasani G, Dai Z, Konieczny BT, Baddoura FK, Lakkis FG.

Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6175-80.

Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue.

Lakkis FG, Arakelov A, Konieczny BT, Inoue Y.

Nat Med. 2000 Jun;6(6):686-8.

 

Review Manuscripts & Editorials:

Innate allorecognition.

Oberbarnscheidt MH, Lakkis FG.

Immunol Rev. 2014 Mar;258(1):145-9. doi: 10.1111/imr.12153.

Immunology: TREG cells in transplantation-a double-edged sword?

Lakkis FG.

Nat Rev Nephrol. 2014 Apr;10(4):185-6. doi: 10.1038/nrneph.2014.35. Epub 2014 Mar 11.

Molecular analysis of transplant rejection: marching onward.

Lakkis FG, Billiar TR.

J Exp Med. 2013 Oct 21;210(11):2147-9. doi: 10.1084/jem.20131810.

Origin and biology of the allogeneic response.

Lakkis FG, Lechler RI.

Cold Spring Harb Perspect Med. 2013 Aug 1;3(8). pii: a014993. doi: 10.1101/cshperspect.a014993.

View Complete Publications Listing

Research Interests

  • Allorecognition in the innate immune system.
  • The biology of memory T cells in organ transplantation.