Lisa Borghesi, PhD

Lisa Borghesi, PhD


Campus: 200 Lothrop St

Office: BSTWR E1056

Pittsburgh, PA 15261

Ph: 412-383-7074

Fax: 412-383-8098


  • PhD - UConn

Academic Affiliation

  • Associate Professor
  • Director, Unified Flow Core
  • Course Director, Immunology in Health & Disease (MS-1)

About Research

Dr. Borghesi's research focuses on HSCs, the sole source of blood forming cells throughout life. It has long been known that infection triggers dramatic and rapid changes in hematopoietic output but the mechanisms remain murky. TLR4 is a dominant innate immune sensor for LPS and hence a model receptor for how the hematopoietic system adapts to pathogen exposure. Her laboratory is studying the mechanisms that enable stem cells to directly sense infection, and functionally respond with accelerated differentiation and/or lineage fate re-direction. Dr. Borghesi is Section Editor at JI and a standing member of CMI-B.


Selected Publications


Liu A, Y Wang, Y Ding, I Baez, K Payne & L Borghesi (2015) Hematopoietic stem cell expansion and common lymphoid progenitor depletion requires hematopoietic-derived, cell-autonomous TLR4 in a model of chronic endotoxin. J Immunol (Cutting-Edge) 195:2524-2528

Liu A, Chen M, Kumar R, Stefanovic-Racic M, O'Doherty RM, Ding Y, Jahnen-Dechent W, & L Borghesi (2018) Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4. Nature Commications. 9:708. short URL:

Sedlacek A, Younker T, Zhou Y, Borghesi L, Shcheglova T, Mandoiu I, Binder RJ (2019) CD91 on dendritic cells governs immunosurvelliance of nascent, emerging tumors. JCI Insight. 4(7) pii:127239

Lab Information

Graduate students interested in rotation opportunities should contact Dr. Borghesi.