Lisa Borghesi, Ph.D.

Lisa Borghesi, Ph.D.


Campus: Biomedical Science Tower, 203 Lothrop St

Office: E1056

Pittsburgh, PA 15261

Ph: 412-383-7074

Fax: 412-383-8098


  • Ph.D. - UConn

Academic Affiliation

  • Professor, Department of Immunology
  • Director, Unified Flow Core
  • Chancellor's Distinguished Teaching Award, 2021
  • Academy of Master Educators, 2022

About Research

Dr. Borghesi's research focuses on HSCs, the sole source of blood forming cells throughout life. It has long been known that infection triggers dramatic and rapid changes in hematopoietic output but the mechanisms remain murky. TLR4 is a dominant innate immune sensor for LPS and hence a model receptor for how the hematopoietic system adapts to pathogen exposure. Her laboratory is studying the mechanisms that enable stem cells to directly sense infection, and functionally respond with accelerated differentiation and/or lineage fate re-direction. Dr. Borghesi is Section Editor at JI and a standing member of CMI-B.


Selected Publications

Weisel N, Weisel F, Farber D, Borghesi L, Shen Y, Ma W and BJ Shlomchik (2020) Comprehensive analysis of B cell compartments across the human body reveals novel subsets and a gut resident memory phenotype. Bloodepub ahead of print blood.2019002782. PMID: 32750113

Sedlacek A, Younker T, Zhou Y, Borghesi L, Shcheglova T, Mandoiu I, Binder RJ (2019) CD91 on dendritic cells governs immunosurvelliance of nascent, emerging tumors. JCI Insight. 4(7) pii:127239

Liu A, Chen M, Kumar R, Stefanovic-Racic M, O'Doherty RM, Ding Y, Jahnen-Dechent W, & L Borghesi (2018) Bone marrow lympho-myeloid malfunction in obesity requires precursor cell-autonomous TLR4. Nature Commications. 9:708. short URL:

Liu A, Y Wang, Y Ding, I Baez, K Payne & L Borghesi (2015) Hematopoietic stem cell expansion and common lymphoid progenitor depletion requires hematopoietic-derived, cell-autonomous TLR4 in a model of chronic endotoxin. J Immunol (Cutting-Edge) 195:2524-2528


Lab Information

Graduate students interested in rotation opportunities should contact Dr. Borghesi.