Alison B Kohan, PhD

Alison B Kohan, PhD

Contact

Campus: 200 Lothrop St

Office: W1056 BST

Pittsburgh, PA 15213

Ph: 412-383-2546

akohan@pitt.edu

Website »

Education

  • BS, University of Arizona, 2000
  • MA, West Virginia University, 2003
  • PhD, West Virginia University, 2009

Academic Affiliation

  • Associate Professor, Medicine, Division of Endocrinology and Metabolism
  • Associare Professor, Immunology

About Research

Dr. Kohan is an expert in the field of intestinal lipoproteins and their metabolism, and the interaction between chylomicron metabolism and inflammation. The consequences of dysfunction in these physiological processes are inflammatory bowel disease and altered whole-body lipid metabolism. Dr. Kohan has made major contributions to understanding the role of chylomicron synthesis and secretion to metabolic and inflammatory disease. She has shown that apolipoprotein C-III, a significant cardiovascular risk factor, plays a critical role in regulating enterocyte cellular metabolism and chylomicron secretion.Dr. Kohan also discovered that the apoC-III content of chylomicrons has a significant role in regulating CD4+T cells and Foxp3+Treg metabolism. Dr. Kohan has also pioneered the primary murine organoid model to study lipoprotein synthesis and secretion by enterocytes. Dr. Kohan’s long-term research goal is to identify and understand mechanisms of intestinal lipoprotein formation, intestinal lipoprotein regulation of immune cells during disease, and to determine how this intestinal lipoprotein/immune system interaction contributes to cardio-metabolic disease progression. Her specific academic mission is to identify and develop clinical treatments based on these findings.

Selected Publications

Li, D., Rodia, C. N., Johnson, Z. K., Bae, M., Muter, A., Heussinger, A. E., Tambini, N., Longo, A. M., Dong, H., Lee, J. Y., Kohan, A. B. Intestinal basolateral lipid substrate transport is linked to chylomicron secretion and is regulated by apoC-III. J Lipid Res. 2019; 60(9): 1503-1515.
 
Botteri, G., Montori, M., Gumà, A., Pizarro, J., Cedó, L., Escolà-Gil, J. C., Li, D., Barroso, E., Palomer, X., Kohan, A. B., Vázquez-Carrera, M. VLDL and apolipoprotein CIII induce ER stress and inflammation and attenuate insulin signalling via Toll-like receptor 2 in mouse skeletal muscle cells. Diabetologia. 2017; 60(11): 2262-2273.
 
West. G., Rodia, C., Li, D., Johnson, Z., Dong, H., Kohan, A. B. Key differences between apoC-III regulation and expression in intestine and liver. Biochem Biophys Res Commun. 2017; 491(3): 747-753.
 
Jattan, J., Rodia, C., Li, D., Diakhate, A., Dong, H., Bataille, A., Shroyer, N. F., Kohan, A. B. Using primary murine intestinal enteroids to study dietary TAG absorption, lipoprotein synthesis, and the role of apoC-III in the intestine. J Lipid Res. 2017; 58(5): 853-865.
 
Kohan, A. B., Yang, Q., Xu, M., Lee, D., Tso, P. Monosodium glutamate inhibits the lymphatic transport of lipids in the rat. Am J Physiol Gastrointest Liver Physiol. 2016; 311(4): G648-G654.
 
Kohan, A. B. Apolipoprotein C-III: a potent modulator of hypertriglyceridemia and cardiovascular disease. Curr Opin Endocrinol Diabetes Obes. 2015; 22(2): 119-25.
 
Kohan, A. B., Wang, F., Lo, C. M., Liu, M., Tso, P. ApoA-IV: current and emerging roles in intestinal lipid metabolism, glucose homeostasis, and satiety. Am J Physiol Gastrointest Liver Physiol. 2015; 308(6): G472-81.
 
Wang, F., Kohan, A. B., Dong, H. H., Yang, Q., Xu, M., Huesman, S., Lou, D., Hui, D. Y., Tso, P. Overexpression of apolipoprotein C-III decreases secretion of dietary triglyceride into lymph. Physiol Rep. 2014; 2(3): e00247.
 
Kohan, A. B., Howles, P. N., Tso, P. Methods for studying rodent intestinal lipoprotein production and metabolism. Curr Protoc Mouse Biol. 2012; 2: 219-230.
 
Kohan, A. B., Wang, F., Li, X., Bradshaw, S., Yang, Q., Caldwell, J. L., Bullock, T. M., Tso, P. Apolipoprotein A-IV regulates chylomicron metabolism-mechanism and function. Am J Physiol Gastrointest Liver Physiol. 2012; 302(6): G628-36.