Liza Konnikova, MD, PhD

Liza Konnikova, MD, PhD

Contact

Campus: 4401 Penn Ave

Office: 7127 Rangos Research Center

Pittsburgh, PA 15224

Ph: 412-692-7346

liza.konnikova@chp.edu

Education

  • B.A., Biology and Chemistry, Brandeis University 1999
  • M.D., Ph.D, Medicine-Physiology, Tufts University 2007

Academic Affiliation

  • Assistant Professor

About Research

Our group is focused on the understanding how neonatal mucosal immunity develops and its role in the pathogenesis of diverse diseases such as sepsis, preterm labor, necrotizing enterocolitis (NEC) and very early onset IBD (VEO-IBD).

In order to improve our understanding of mucosal immunity, we use a number of single cell based techniques including mass cytometry or CyTOF) to understand diverse interactions between the immune and epithelial components of the GI tract both during development (from fetal to adult tissue) as well as in disease. In addition to continuing studies on GI immune development in infants and young children, currently my lab is applying these techniques to gain a better understanding of placental immune development and postulate that there are potential infection independent immune triggers in the placenta that induce preterm labor and set up a proinflammatory cascade in the infants. 

Selected Publications

Liza Konnikova, Maciej Kotecki, Mathew M Kruger and Brent H Cochran. Knockdown of STAT3 expression by RNAi induces apoptosis in astrocytoma cells. BMC Cancer. 2003;3(1):23. PMCID: PMC212316

Liza Konnikova, Marina C Simeone, Mathew M Kruger, Maciej Kotecki, Brent H Cochran. Signal transducer and activator of transcription 3 (STAT3) regulates human telomerase reverse transcriptase (hTERT) expression in human cancer and primary cells. Cancer Res. 2005;65(15):6516-20. PMID: 16061629

Liza Konnikova, MD PhD, Munir M. Zaman, MD, Meher Makda, Danila D’Onofrio, Steven D. Freedman, MD PhD, Camilia R. Martin MD.  Late Enteral Feedings are Linked to Intestinal Inflammation and Adverse Neonatal Outcomes. PLoS One. 2015 Jul 14;10(7):e0132924.

Margaret G. Parker, MD, MPH, Liza Konnikova, MD, PhD, Camilia R. Martin, MD, MS. The Role of Nutrition in Health and Disease in Premature Infants: Current Knowledge Gaps and Defining the Research Agenda. In: Nutrition and Infancy, Dr. Ronald Watson. 1 Springer Science + Business Media; 2013.

Sefik E, Geva-Zatorsky N, Oh S, Konnikova L, Zemmour D, McGuire AM, Burzyn D, Ortiz-Lopez A, Lobera M, Yang J, Ghosh S, Earl A, Snapper SB, Jupp R, Kasper D, Mathis D, Benoist C. Individual intestinal symbionts induce a distinct population of RORγ⁺ regulatory T cells. Science. 2015 Aug 28;349(6251):993-7. doi: 10.1126/science.aaa9420. PMCID: PMC4700932

Dror S Shouval, Amlan Biswas, Yu Hui Kang, Alexandra E. Griffith, Liza Konnikova, Ivan D. Mascanfroni, Naresh S Redhu, Sandra M Frei, Michael Field, Andria L Doty, Jeffrey D. Goldsmith, Atul K Bhan, Anthony Loizides, Batia Weiss, Baruch Yerushalmi, Tadahiro Yanagi, Xiuli Lui, Francisco J Quintana, Alexo M Muise, Christoph Klein, Bruce H. Horwitz, Sarah C Glover, Athos Bousvaros, Scott B Snapper.  Innate Immune IL1B Production is Critical in Mediating Intestinal Inflammation in IL10 Receptor Deficiency in Mice and Humans.  Gastroenterology.  2016 Dec;151(6):1100-1104. doi: 10.1053. PMCID: PMC5124405

Michael A. Silverman*, Liza Konnikova*, and Jeffrey S. Gerber.  Impact of antibiotics on necrotizing enterocolitis and antibiotics-associated diarrhea.  Gastorenterology Clinics of North America. 46(1):61-76. doi: 10.1016/j.gtc.2016.09.010. *=equal first authors

Dror S. Shouval*, Liza Konnikova*, Alexandra E. Griffith, Sarah M. Wall3, Lael Werner, Moran Nunberg, Jeremy A. Goettel, Rajsavi Anand, Batia Weiss, Jian Li, Anthony Loizides, Baruch Yerushalmi, Tadahiro Yanagi, Rita Beier, Laurie S. Conklin, Christen L. Ebens, Fernanda G.M.S. Santos, Mary Sherlock, Jeffery D. Goldsmith, Daniel Kotlarz, Sarah C. Glover, Aleixo M. Muise, Christoph Klein, Scott B. Snapper.  Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD. Inflamm Bowel Dis. 2017 Nov;23(11):1950-1961. doi: 10.1097/MIB.0000000000001270 *=equal first authors

Daniel Kotlarz, Benjamin Marquardt, Tuva Barøy, Way S. Lee, Liza Konnikova, Sebastian Hollizeck, Thomas Magg, Anna S. Lehle, Christoph Walz, Ingo Borggraefe, Fabian Hauck, Philip Bufler, Raffaele Conca, Sarah M. Wall, Eva M. Schumacher, Doriana Misceo, Eirik Frengen, Beint S. Bentsen, Holm H. Uhlig, Karl-Peter Hopfner, Aleixo M. Muise, Scott B. Snapper, Petter Strømme, and Christoph Klein. Human TGF-β1 deficiency causes severe inflammatory bowel disease and neurodevelopmental delay. Nature Genetics (accepted).

Research Interests

  • Computational Biology
  • Developmental Biology
  • Signaling