Martin Oberbarnscheidt, MD, PhD

Martin Oberbarnscheidt, MD, PhD

Contact

Campus: 200 Lothrop Street

Office: W1500 BST

Pittsburgh, PA 15261

Ph: 412-648-1491

mho6@pitt.edu

Education

  • MD, Freie Universität Berlin, Germany
  • PhD, Freie Universität Berlin, Germany

Academic Affiliation

  • Assistant Professor, Surgery
  • Assistant Professor, Immunology

About Research

Local immune responses in Transplantation
 
We are investigating the initial steps of allorecognition by monocytes, interaction of T cells with innate immune cells in the graft and the role of chronic inflammation resulting in local formation of ectopic tertiary lymphoid organs and their contribution to the rejection response. 
 
My NIH-funded lab is currently investigating factors governing the formation of TLO and characterizing the immune processes propagated locally therein, including T cell and B cell responses. The gaol of my research is to understand the factors contributing to sustained allorecognition, chronic rejection and organ failure in order to develop new strategies to improve allograft outcome and patient lives.
 
Renal DC network
 
The mammalian kidney has an extensive network of mononuclear phagocytes whose function is not fully understood. We have shown that CX3CR1+ dendritic cells encase the microvasculature in the renal cortex, extend dendrites into the post-capillary venules and capture antigens from the blood. Two-photon intravital microscopy is used to study cell-cell interactions and morphology of renal DC in different disease models.

Selected Publications

Dr. Oberbarnscheidt's full list of publications can be viewed on PubMed