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Amanda Poholek Ph.D.

  • Assistant Professor, Department of Immunology
  • Director, Health Sciences Sequencing Core
  • PMI Graduate Faculty

    Education & Training

  • Postdoctoral Fellow, National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases, 2012-2015
  • Postdoctoral Fellow, National Institutes of Health/National Institute of Allergy and Infectious Diseases, 2009-2011
  • PhD in Cell Biology, Yale University, 2009
  • BS in Biological Sciences, Fordham University, 2002
Representative Publications

Click here for a complete list of publications.

Research Interests

The Poholek Lab uses cutting edge technologies and systems approaches to understand how tissue environmental signals impact immune cell differentiation and function. We are currently exploring the lung specific factors that promote allergic asthma, and how the tumor microenvironment impacts T cell exhaustion.

Current Projects:

  1. Tissue specific functions of the transcriptional repressor Blimp-1 in CD4 T cells and ILC2s
  2. Cell type and disease specific epigenetic control of Blimp-1 in immune cells
  3. Epigenetic landscape of T cell exhaustion in the tumor
  4. immunotherapeutic approaches targeting the epigenome in cancer
  5. Identifying immunological spatial niches using spatial transcriptomics technologies