Faculty and students with interests in tumor immunology are on the leading edge of research in tumor antigen discovery, antigen presentation with special emphases on dendritic cells, lymphocyte specificity and activation, cytokine action, and in vivo vaccination strategies to develop safe and effective treatments for cancer by enhancing anti-cancer immune responses. Related studies in this area include the search for underlying genetic or biochemical defects that lead to cell transformation and tumorigenesis, which may also influence tumor immunogenicity. These studies emphasize intracellular signal transduction, programmed cell death, and oncogene function. Members also study the development, activation, and function of natural killer cells.
Participating Faculty and Lab
Robert Binder, Ph.D.
Antigen processing and presentation; cross priming; mechanisms of tumor immunology; immunosurveillance
Greg M. Delgoffe, Ph.D
Metabolism of antitumor immunity, tumor immunotherapy
Olivera J. Finn, Ph.D.
Human T cell biology; tumor immunology; transplant immunology
Adrianna Larregina, M.D., Ph.D.
Skin genetic immunization; immunobiology of skin; bone marrow derived DCs
Jing Li, Ph.D.
Regulatory CD8+ T cells; cancer immunology; maternal tolerance during pregnancy
Michael T. Lotze, M.D.
Tumor immunology; dendritic cell biology; cytokine biology; regulation of apoptosis in immune effectors
Penelope A. Morel, M.D.
Thl/Th2 regulation; autoimmunity; NK cell biology
Amanda Poholek, Ph.D.
Transcriptional and epigenetic control of T cell differentiation
Abby Overacre, Ph.D.
Microbiome, diet, tumor immunology, immunotherapy, immunoregulation
Michael R. Shurin, M.D., Ph.D.
Tumor immunology; dendritic cell biology
Walter J. Storkus, Ph.D.
Natural killer cell and CTL antitumor targeting mechanisms
Dario Vignali, Ph.D.
Focus on the impact of inhibitory receptors (LAG3 and PD1) and regulatory T cells on the tumor microenvironment, mechanisms of intratumoral T cell exhaustion, and the development of novel immunotherapeutics
Zhaoyang You, Ph.D.
In Vivo Targeted Vaccines for Tumor Immunotherap
Hassane Zarour, M.D.
MHC class II tumor epitopes