- University of Chicago, Postdoc
- Medical University Innsbruck – Austria, Ph.D. (2012)
- University of Applied Sciences Vienna – Austria, M.S. (2007)
Education & Training
1) Pandey SP#, Yang D#, Hedden L#, Laughlin CR, Wang W, Soto AS, Winner H, Medina Sanchez L, Campana EE, Engl C, Zeng Y, Rana M, Van Der Kraak L, Bender MJ, Prokopec J, Ferrick JM, Meng X, Fong E, Sun M, Mullett S, MacDonald M, Gelhaus S, Watkins SC, Meisel M, von Moltke J, Xu S, Gong YN*, Hinterleitner R*. Gasdermin C cleavage by Cathepsin S modulates Rab7 vesicles in intestinal epithelial cells to amplify anti-helminth immunity. Immunity 2025 Jul 16:S1074-7613(25)00287-0. PMID: 40701157 #* contributed equally Highlighted in Immunity
2) Medina Sanchez L#, Siller M#, Zeng Y#, Brigleb PH, Sangani KA, Soto AS, Engl C, Laughlin CR, Rana M, Van Der Kraak L, Pandey SP, Bender MJ, Fitzgerald B, Hedden L, Fiske K, Taylor GM, Wright AP, Mehta ID, Rahman SA, Galipeau HJ, Mullett SJ, Gelhaus SL, Watkins SC, Bercik P, Nice TJ, Jabri B, Meisel M, Das J, Dermody TS, Verdú EF, Hinterleitner R. The gut protist Tritrichomonas arnold restrains virus-mediated loss of oral tolerance by modulating dietary antigen-presenting dendritic cells. Immunity 2023 Jul 11;S1074-7613(23)00279-0. # contributed equally. PMID: 37478853 Highlighted in Trends in Immunology
3) Galipeau HJ, Hinterleitner R, Leonard MM, Caminero A. Non-host factors influencing onset and severity of celiac disease. Gastroenterology 2024 Jan 27:S0016-5085(24)00068-4. PMID: 38286392
4) Hinterleitner R#, Meisel M#, Pacis A, Chen L, Earley ZM, Mayassi T, Pierre JF, Ernest JD, Galipeau HJ, Thuille N, Bouziat R, Buscarlet M, Ringus DL, Wang Y, Li Y, Dinh V, Kim SM, McDonald BD, Zurenski MA, Musch MW, Furtado G, Lira S, Baier G, Chang EB, Eren MA, Weber CR, Busque L, Godley LA, Verdú EF, Barreiro LB, Jabri B. Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host. Nature 2018 May;557(7706):580-584. # contributed equally. PMID: 29769727 Highlighted in Cancer Discovery, The Hematologist, Science Daily and various other news and media outlets.
5) Hinterleitner R#, Bouziat R#, Brown JJ#, Stencel-Baerenwald JE, Ikizler M, Mayassi T, Meisel M, Kim SM, Discepolo V, Pruijssers AJ, Ernest JD, Iskarpatyoti JA, Costes LMM, Lawrence I, Palanski BA, Varma M, Zurenski MA, Khomandiak S, McAllister N, Aravamudhan P, Boehme KW, Hu F, Samsom JN, Reinecker HC, Kupfer SS, Guandalini S, Semrad C, Abadie V, Khosla C, Barreiro LB, Xavier RJ, Ng A, Dermody TS, Jabri B. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science 2017 Apr 7;356(6333):44-5 # contributed equally. PMID: 28386004 Perspective in Science, New England Journal of Medicine, J Cell Physiol. Highlighted in Science Immunology, Nature Reviews Gastroenterology and Hepatology
Dr. Reinhard Hinterleitner’s research focuses on how intestinal microbes—particularly commensal protists—and enteric infections shape mucosal immunity, oral tolerance, and inflammatory diseases such as celiac disease and IBD. His lab combines immunology, microbiology, and epithelial cell biology to uncover molecular mechanisms, including a novel Cathepsin S–Gasdermin C pathway that regulates lipid metabolism and type 2 immunity. Through these studies, his group aims to reveal how host–microbe interactions at the gut barrier influence systemic immune responses and can be leveraged for therapeutic innovation.