- Washington and Jefferson College, BA in Biochemistry, Minor in Philosophy (2011)
- University of Pittsburgh MSTP, PhD in Immunology (2016), MD (2018)
- Postdoc - Pediatric Residency 2018-2020, Allergy/Immunology fellowship 2020-2024, postdoctoral training in the lab of Dr. John Williams
Education & Training
Eddens, T., Parks, O.B., Zhang, Y., Manni, M.L., Casanova, J.L., Ogishi, M., Williams, J.V. 2024. PD-1 dependent inhibition of neonatal CD8+ protects against respiratory viral immunopathology. Mucosal Immunol. Jan3:S1933-0219(23)00100-9. PMID:38176655
Eddens, T.*, Parks, O.B.*, Lou, D., Fan, L., Sojati, J., Ramsey, M.J., Schmitt, L., Salgado, C.M., Reyes-Mugica, M., Oury, T.D., Byersdorfer, C.A., Chen, K., Williams, J.V. 2024. Monocyte production of C1q potentiates CD8+ T cell effector function following respiratory viral infection. AJRCMB . Sept;71(3):294-306. * denotes co-first authors. PMCID: PMC11376238
Eddens, T., Parks, O.B., Williams, J.V. 2022. Neonatal Immune Responses to Respiratory Viruses. Front. Immun. Apr 14;13:863149. PMCID: PMC9047724.
Eddens, T., Rangel-Moreno, J., Castillo, P., Serody, K., Elsegeiny, W., Garcia-Hernandez, M.d.l.L, Campfield, B.T., Khader, S.A., Chen, K., Kolls, J.K. 2016. Pneumocystis driven inducible bronchus associated lymphoid tissue formation requires Th2 and Th17 immunity. Cell Reports 18: 3078–3090. PMCID: PMC5411079.
Eddens, T., Campfield, B. T., Serody, K., Manni, M. L., Horne, W., Elsegeiny, W., McHugh, K. J., Pociask, D., Chen, K., Zhen, M., Alcorn, J. F., Wenzel, S., and Kolls, J. K. 2016. A Novel CD4(+) T-cell Dependent Murine Model of Pneumocystis Driven Asthma-like Pathology. Am J Respir Crit Care Med. 194: 807-820. PMCID: PMC5074654.
URL link to list of all publications (PubMed/GoogleScholar/etc.): https://www.ncbi.nlm.nih.gov/myncbi/1Bu9N0BvlrLkK/bibliography/public/
The Eddens lab studies the acute and long-standing pathology following early life respiratory viral infection. Viral pathogens are major cause of morbidity and mortality in young children. Early life viral infection is also associated with an increased risk of developing asthma. We model early life viral infection using a neonatal mouse model of human metapneumovirus infection. The immune system in neonates and infants is regulated in a manner that favors tolerogenic and anti-inflammatory responses to common stimuli, such as viruses. These differences are present in many cell types, with our lab currently focusing on T cells. CD4+ T cells in neonates skew towards a Th2 phenotype. This Th2 bias seems to persist throughout life, as we have found that mice reinfected with HMPV after an initial neonatal infection develop asthma-like inflammation. Our lab is currently evaluating tissue resident memory cells after neonatal infection and their role in virus-induced asthma. We are also examining transcriptional differences within neonatal CD4+ T cells and how these responses are shaped by local signals in the developing lung.