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Yoram Vodovotz Ph.D.

  • Professor, Department of Surgery, University of Pittsburgh School of Medicine
  • Professor, Department of Immunology, University of Pittsburgh School of Medicine
  • Professor of Computational and Systems Biology, University of Pittsburgh School of Medicine
  • Professor of Bioengineering, University of Pittsburgh
  • Member, McGowan Institute for Regenerative Medicine, Wound Healing Section
  • Member, University of Pittsburgh Molecular Medicine Institute

    Education & Training

  • Postdoc - Radiation Biology Branch, National Cancer Institute, National Institutes of Health (1996-1997)
  • Postdoc - Laboratory of Chemoprevention, National Cancer Institute, National Institutes of Health (1993-1996)
  • Postdoc - Cornell University (1993)
  • Ph.D. - Cornell University (1993)
  • B.S. - University of Wisconsin-Madison (1988)
Representative Publications

Kumar, R.; Clermont, G.; Vodovotz, Y.; Chow, C. C. The dynamics of acute inflammation. J.Theoretical Biol. 2004. 230:145-155.

2. Clermont, G.; Bartels, J.; Kumar, R.; Constantine, G.; Vodovotz, Y.; Chow, C. In silico design of clinical trials: a method coming of age. Crit Care Med. 2004. 2004; 32:2061-2070

3. Chow, C. C.; Clermont, G.; Kumar, R.; Lagoa, C.; Tawadrous, Z.; Gallo, D.; Betten, B.; Bartels, J.; Constantine, G.; Fink, M. P.; Billiar, T. R.; Vodovotz, Y. The acute inflammatory response in diverse shock states. Shock 2005; 24:74-84.

4. Prince, J.M.; Levy,R.M.; Bartels, J.; Baratt, A.; Kane, J.M. III; Lagoa, C.; Rubin, J.; Day, J.; Wei, J.; Fink, M.P.; Goyert, S.; Clermont, G.; Billiar, T.R.; Vodovotz, Y. In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice. Mol. Med., 2006. 12:88-96. PMC1578765

5. Lagoa, C.E.; Bartels, J.; Baratt, A.; Tseng, G.; Clermont, G.; Fink, M.P.; Billiar, T.R.; Vodovotz, Y. The role of initial trauma in the host’s response to injury and hemorrhage: Insights from a comparison of mathematical simulations and hepatic transcriptomic analysis. Shock, 2006. 26:592-600.

6. Li, N.Y.K.; Verdolini, K.; Clermont, G.; Mi, Q.; Hebda, P.A.; Vodovotz, Y. A patient-specific in silico model of inflammation and healing tested in acute vocal fold injury. PLoS ONE. 2008. 3:e2789. PMC2481293

7. Vodovotz, Y., Csete, M.; Bartels, J.; Chang, S.; An, G. Translational systems biology of inflammation. PLoS Comput. Biol. 2008. 4:1-6. PMC2329781

8. Mi, Q.; Constantine, G.; Ziraldo, C.; Solovyev, A.; Torres, A.; Namas, R.; Bentley, T.; Billiar, T.R.; Zamora, R.; Puyana, J.C.; Vodovotz, Y. A dynamic view of trauma/hemorrhage-induced inflammation in mice: Principal drivers and networks. PLoS ONE. 2011. 2011.6:19424. PMCID: PMC3091861

9. Nieman, G.; Brown, D.; Sarkar, J.; Kubiak, B.; Ziraldo, C.; Vieau, C.; Barclay, D.; Gatto, L.; Maier, K.; Zamora, R.; Mi, Q.; Chang, S.; Vodovotz, Y. A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine. Crit. Care Med. 2012. 40:1052-1063. PMCID: PMC3308118

10. Azhar, N.; Ziraldo, C.; Barclay, D.; Rudnick, D.; Squires, R.; Vodovotz, Y. Analysis of serum inflammatory mediators identifies unique dynamic networks associated with death and spontaneous survival in pediatric acute liver failure. PLoS ONE. 2013. 8:e78202.

11. Namas, R.A.; Bartels, J.; Hoffman, R.; Barclay, D.; Billiar, T.R.; Zamora, R.; Vodovotz, Y. Combined in silico, in vivo, and in vitro studies shed insights into the acute inflammatory response in middle-aged mice. 2013. PLoS ONE. 2013. 8: e67419. PMCID: PMC3699569

12. Solovyev, A.; Mi, Q.; Tzen, Y-T.; Brienza, D.; Vodovotz, Y. Hybrid equation- / agent-based model of ischemia-induced hyperemia and pressure ulcer formation predicts greater propensity to ulcerate in subjects with spinal cord injury. PLoS Comput. Biol. 2013. 9:e1003070. PMCID: PMC3656105

13. Vodovotz, Y.; Billiar, T.R. In silico modeling: Methods and applications to trauma and sepsis. Crit. Care Med. 2013. 41:2008-2014. PMCID: PMC3722589

14. Complex Systems and Computational Biology Approaches to Acute Inflammation. An, G.; Vodovotz, Y., eds. New York, NY: New York, NY: Springer. 2013.

15. Zaaqoq, A.M.; Namas, R.; Almahmoud, K.; Azhar, N.; Mi, Q.; Zamora, R.; Brienza, D.M.; Billiar, T.R.; Vodovotz, Y. IP-10, a potential driver of neurally-controlled IL-10 and morbidity in human blunt trauma. Crit. Care Med. 2014. 42:1487-1497.

16. Translational Systems Biology: Concepts and Practice for the Future of Biomedical Research. An, G. and Vodovotz, Y. New York, NY: Elsevier. 2014.

Research Interests

My long-term research goals are to obtain high-dimensional, dynamic data on the etiology and progression of various inflammatory processes and diseases in samples derived from cells, animals, and people; to create computational models based on these data; and to modulate the inflammatory response in an optimal spatial, temporal, and individual- / disease-specific manner.