Rachel A. Gottschalk, Ph.D.
Contact
Campus: The Assembly, 5051 Centre Ave
Office: 3043
Pittsburgh, PA 15213
Ph: 412-383-0473
Education
- B.S., Biology, Emory University, 2005
- Ph.D., Immunology, Weill Cornell Graduate School of Medical Sciences, 2012
- Post-doctoral Fellowship, Laboratory of Systems Biology, NIAID, NIH
Academic Affiliation
- Assistant Professor, Department of Immunology
About Research
Our lab uses quantitative approaches to understand how macrophages process stimuli to determine the appropriate functional response. Major projects include (1) linking phosphorylation dynamics to kinase and transcription factor specificity, (2) interrogating lung-specific macrophage signaling, and (3) dissecting molecular determinants of macrophage polarization. We combine experimental and computational approaches to link intracellular signaling, gene expression, and immune function, promising insight into disease susceptibility and potential therapeutic manipulation of macrophage function.
Selected Publications
Myers S.A.# and Gottschalk R.A.# Mechanisms encoding STAT functional diversity for context-specific inflammatory responses. Curr. Opin. Immunol. 2022. PMID: 35063833
#co-corresponding authors
Shoger K.E., Cheemalavagu N., Cao Y.M., Michalides B.A., Chaudhri V.K., Cohen J.A., Singh H., Gottschalk R.A. CISH attenuates homeostatic cytokine signaling to promote lung-specific macrophage programming and function. Sci. Signal. 2021. PMID: 34516753
Gottschalk R.A.*#, Dorrington M.G.*, Dutta B., Krauss K.S., Martins A.J., Uderhardt S., Chan W., Tsang J.S., Torabi-Parizi P., Fraser I.D., Germain R.N.#. IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses. eLIFE. 2019. PMID: 31385572
*co-first authors, #co-corresponding authors
Oh K.S.*, Gottschalk R.A.*#, Lounsbury N.W.*, Sun J., Dorrington M.G., Baek S., Sun G., Wang Z., Krauss K.S., Milner J.D., Dutta B., Hager G.L., Sung M.H., Fraser I.D.# Dual roles for Ikaros in regulation of macrophage chromatin state and inflammatory gene expression. J. Immunol. 2018. PMID: 29898962
*co-first authors, #co-corresponding authors
Oh K.S., Patel H., Gottschalk R.A., Lee W.S., Baek S., Fraser I.D., Hager G.L., Sung M.H. Anti-inflammatory chromatinscape suggests alternative mechanisms of glucocorticoid receptor action. Immunity. 2017. PMID: 28801231
Gottschalk R.A.*, Martins A.J., Angermann B.R., Dutta B., Ng C.E., Uderhardt S., Tsang J.S., Fraser I.D., Meier-Schellersheim M., Germain R.N.* Distinct NF-kB and MAPK activation thresholds uncouple steady-state microbe sensing from anti-pathogen inflammatory responses. Cell Systems, 2016. PMID: 27237739
*co-corresponding authors
Research Interests
- Macrophage signaling
- Quantitative control of inflammation
- Tissue-specific macrophage function
- Computational and systems biology