Douglas Prado Ph.D.

1. Douglas S. Prado, Achyudhan R. Kutuva, Richard T. Cattley, Andreza Buzolin SOnego, 
Parth Sutariya, Elena Im, Shuxian Wu, Mijoon Lee, Rachel L. Cumberland, Isha Mehta, 
Greg M. Delgoffe, William C. Boggess, James R. Faeder, Mark J. Shlomchik, William F. 
Hawse. STAT3 S727 phosphorylation drives pathogenic Th17 differentiation and 
neuroinflammation in autoimmune disease. Journal of Neuroinflammation, 2025.

2. PRADO, D.S., CATTLEY, R. T., SONEGO, A.B., SUTURIYA, P., WU, S., LEE, M., 
BOGGESS, W.C., SHLOMCHIK, M. J., HAWSE, F. W. The phospholipid kinase PIKFYVE 
is essential for Th17 differentiation. Journal of Experimental Medicine, 2025.

3. COSTA, R.M., CERQUEIRA, D.M., BRUDER-NASCIMENTO, A., ALVES, J.V., AWATA, 
W.M.C., SINGH, S., KUFNER, A., PRADO. D.S., JOHNY, E., CIFUENTES-PAGANO, E. 
HAWSE, W.F., DUTTA, P., PAGANO, P.J., HO, J. BRUDER-NASCIMENTO, T. Role of the 
CCL5 and Its Receptor, CCR5, in the Genesis of Aldosterone-Induced Hypertension, 
Vascular Dysfunction, and End-Organ Damage. Hypertension. 2024. 81, 776-786.

4. PRADO, Douglas S.; CATTLEY, RICHARD T.; SHIPMAN, COREY W.; HAPPE, 
CASSANDRA; LEE, MIJOON; BOGGESS, WILLIAM C.; MACDONALD, MATTHEW L.; 
HAWSE, WILLIAM F. Synergistic and additive interactions between receptor signaling 
networks drive the regulatory T cell versus T helper 17 cell fate choice. Journal of 
Biological Chemistry, 2021

5. PRADO, D.S.; DAMASCENO, L.E.A.; SONEGO, A.B.; ROSA, M.H.; ARTINS, T.V.;
FONSECA, M.D.M.; CUNHA, T.M.; CUNHA, F.Q.; ALVES-FILHO, J.C. Pitavastatin
ameliorates autoimmune neuroinflammation by regulating the Treg/Th17 cell 
balance through inhibition of mevalonate metabolism. International 
Immunopharmacology, v. 91, p.1-10, 2021.

6. PRADO, D.S.; VERAS, F. P.; FERREIRA, R. G.; DAMASCENO, L. E. A.; MELO, P. H.; 
ZAMBONI, DARIO S.; CUNHA, T. M.; CUNHA, F. Q.; ALVES-FILHO, J. C. NLRP12 
controls arthritis severity by acting as a chekpoint inhibitor of Th17 cell 
differentiation. FASEB Journal, v. 34, p. 10907-10919, 2020.

7. DAMASCENO, L. E. A.; PRADO, D.S.; VERAS, F. P.; FONSECA, M. D. M.; KAWAHISA, 
J.E.T.; ROSA, M. H.; PUBLIO, G. A.; MARTINS, T. V.; RAMALHO, F. S.; WAISMAN, A.; 
CUNHA, F.Q.; CUNHA, THIAGO M.; ALVES-FILHO, JOSE C. PKM2 promotesTh17 cell 
differentiation and autoimmune inflammation by fine-tuning STAT3 
activation. Journal of Experimental Medicine, v. 217, p. 1-16, 2020.

8. LUIZ, JOÃO PAULO M.; TOLLER'KAWAHISA, JULIANA E.; VIACAVA, PAULA R.;
NASCIMENTO, DANIELE C.; PEREIRA, PRISCILLA T.; SARAIVA, ANDRÉ L.; PRADO,
Douglas S.; LEBERT, MARC; GIURISATO, EMANUELE; TOURNIER, CATHY; CUNHA, 
THIAGO M.; CUNHA, FERNANDO Q.; QUESNIAUX, VALERIE; RYFFEL, BERNHARD; 
ALVES-FILHO, JOSÉ C. MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage 
differentiation through regulation of c-Myc expression. Journal of Leukocyte 
Biology, v. 108, p.1215-1223, 2020.

9. TAIRA, T.M.; LIMA, V.; PRADO, D.S.; SILVA, T.A.; ISSA, J.P.M.; DA SILVA, L.A.B.; 
ZAMBONI, D.S.; CUNHA, F.Q.; FUKADA, S.Y. NLRP12 Attenuates Inflammatory Bone 
Loss in Experimental Apical Periodontitis. Journal of Dental Research, v. 98, p. 476-
484,2019.

10. FERREIRA, RAPHAEL G.; RODRIGUES, LILIAN C.; NASCIMENTO, DANIELE C.; 
KANASHIRO, ALEXANDRE; MELO, PAULO H.; BORGES, VANESSA F.; GOZZI, 
ALINE; DA SILVA PRADO, DOUGLAS; BORGES, MARCOS C.; RAMALHO, FERNANDO 
S.; STOWELL, SEANR.; CUMMINGS, RICHARD D.; DIAS-BARUFFI, MARCELO; 
CUNHA, FERNANDO Q.; ALVES-FILHO, JOSE C. Galectin-3 aggravates experimental 
polymicrobial sepsis by impairing neutrophil recruitment to the infectious 
focus. Journal of Infection, v. 18, p.1-7, 2018.

11. SONEGO, ANDREZA B.; PRADO, Douglas S.; VALE, GABRIEL T.; SEPULVEDA-DIAZ, 
JULIA E.; CUNHA, THIAGO M.; TIRAPELLI, CARLOS R.; DEL BEL, ELAINE A.; RAISMANVOZARI, RITA; GUIMARÃES, FRANCISCO S. Cannabidiol prevents haloperidol-
inducedvacuoschewing movements and inflammatory changes in mice via 
PPARγreceptors. Brain, Behavior and Immunity, v. 74, p. 241-251, 2018.

12.CAMPA, CARLO C.; SILVA, RANGEL L.; MARGARIA, JEAN P.; PIRALI, TRACEY; MATTOS, 
MATHEUS S.; KRAEMER, LUCAS R.; REIS, DIEGO C.; GROSA, GIORGIO; COPPERI, 
FRANCESCA; DALMARCO, EDUARDO M.; LIMA-JÚNIOR, ROBERTO C. P.; APRILE, 
SILVIO; SALA, VALENTINA; DAL BELLO, FEDERICA; PRADO, DOUGLAS 
SILVA; ALVES-FILHO, JOSE CARLOS; MEDANA, CLAUDIO; CASSALI, GEOVANNI D.; 
TRON, GIAN CESARE; TEIXEIRA, MAURO M.; CIRAOLO, ELISA; RUSSO, REMO C.; 
HIRSCH, EMILIO. Inhalation of the prodrug PI3K inhibitor CL27c improves lung 
function in asthma and fibrosis. Nature Communications, v. 9, p. 1-16, 2018