August 18, 2026 | By Asher Jones
As the immune system battles cancer, chronic stimulation gradually drives T cells to a state of exhaustion. But some of these exhausted T cells can lose expression of the exhaustion marker LAG3, move out of the tumor, and confer long-lasting immunity to cancer in mice, according to a surprising new study published in the Journal of Experimental Medicine that describes a new method to track these cells for the first time.