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BLIMP1 Controls Identity of Immune Cells That Promote Allergic Asthma

May 5, 2026 | By Asher Jones

New research published in Nature Immunology shows that a transcription factor called BLIMP1 is essential for maintaining the identity of type 2 innate lymphoid cells (ILC2s) in a mouse model of allergic asthma, shedding light on how these cells promote allergy in asthmatic patients.

BLIMP1 Acts as a Molecular Brake to Balance B Cell Breadth

April 20, 2026 | By Asher Jones

The immune system faces a tradeoff during infection or after vaccination: It must select for B cells with potent antibodies that efficiently eliminate pathogens, while also maintaining a breadth of B cells that recognize other antigens—or risk getting caught off guard if the pathogen mutates.